Drug Interactions and Antiretroviral Drug Monitoring
نویسندگان
چکیده
منابع مشابه
Therapeutic drug monitoring and drug-drug interactions involving antiretroviral drugs.
The consensus of current international guidelines for the treatment of HIV infection is that data on therapeutic drug monitoring (TDM) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (Pls) provide a framework for the implementation of TDM in certain defined scenarios in clinical practice. However, the utility of TDM is considered to be on an individual basis ...
متن کاملEmerging antiretroviral drug interactions.
With HIV-infected patients living longer and recommendations to initiate antiretrovirals (ARVs) being made earlier, the likelihood for potential drug-drug interactions between ARVs and concurrent medications used to manage co-morbid conditions will increase. In order to maximize the clinical benefit and minimize potential toxicity of ARVs and co-administered medications, it is important for cli...
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Knowledge of drug interactions among antiretroviral agents and other drugs used by HIV-infected patients is essential to maintaining safety and efficacy of drug treatment. Often, the clinical impact of drug-drug interactions cannot be predicted on the basis of pharmacokinetic interactions alone, highlighting the need for studies and analyses that provide exposure-response data. Drug interaction...
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Antiretrovirals are prone to drug-drug and drug-food interactions that can result in subtherapeutic or supratherapeutic concentrations. Interactions between antiretrovirals and medications for other diseases are common due to shared metabolism through cytochrome P450 (CYP450) and uridine diphosphate glucuronosyltransferase (UGT) enzymes and transport by membrane proteins (e.g., p-glycoprotein, ...
متن کاملAntiretroviral Drug Interactions and Adverse Side Effects
The complexity of antiretroviral therapy, coupled with the lifelong duration of treatment, presents the need for extensive management of drug interactions and adverse effects. This article includes an extensive discussion of drug interactions involving antiretroviral agents and other medications (eg, antibiotics, oral contraceptives, H2 antagonists, and lipid-lowering agents) commonly used in i...
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ژورنال
عنوان ژورنال: Current HIV/AIDS Reports
سال: 2014
ISSN: 1548-3568,1548-3576
DOI: 10.1007/s11904-014-0212-1